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| UniProt ID |
P78423 |
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| Entry Name |
X3CL1_HUMAN |
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| Protein Name |
Fractalkine |
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| Primary Gene Name |
CX3CL1 |
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| Organism |
Homo sapiens (Human) |
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| Molecular Function |
Cytokine |
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| Membrane Location |
Secreted |
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| Substrate Name | Fractalkine (CX3CL1) | |
| Cell Type | endothelial cell | |
| Substrate Description | Leukocyte Recruitment - Chemokine recruitment of leukocytes,Firm adhesion and locomotion to the endothelial cell junction | |
| Substrate Function Category | Immune and Inflammation | |
| Substrate Function Subtype | Immune and Inflammation; cytokine | |
| Sheddase | ADAM17, ADAM10 | |
| Shedding-related Disease | cytokine | |
| Short Summary of Papers | neuroprotective, soluble chemoattractant, decreased endothelial adhesiveness, de-adhesion of bound leukocytes | |
| Cleavage Information | NONE | |
| PMID | 16565325 11495925 18951988 |
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Start | End |
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25 | 341 |
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342 | 362 |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| PMAP | No_information | ADAM10 peptidase | This entry is based on an experiment | 12714508 | ||||
| PMAP | No_information | ADAM17 peptidase | This entry is based on an experiment | Gel electrophoresis | 10770945 11238035 11495925 | |||
| PMAP | No_information | ADAM10 peptidase | This entry is based on an experiment | Gel electrophoresis | 12714508 17548644 | |||