UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

P78348
Entry Name

ASIC1_HUMAN
Protein Name

Acid-sensing ion channel 1
Primary Gene Name

ASIC1
Organism

Homo sapiens (Human)
Molecular Function

Ion channel
Sodium channel
Membrane Location

Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name Acid-sensing ion channel 1 (ASIC1)
Cell Type
Substrate Description proton-gated sodium channels
Substrate Function Category growth factor & growth hormone
Substrate Function Subtype
Sheddase Matriptase
Shedding-related Disease ion channel
Short Summary of Papers matriptase cleavages and decreases the function of ASIC1.
Cleavage Information NONE
PMID 20601429



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Transmembrane
 		46 69
Extracellular
 		70 427
Transmembrane
 		428 454



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
PAPER ANFR*SFKP 145 Matriptase 20601429   
PAPER EDFK*VVFT 185 Matriptase 20601429   
PAPER IPSK*ASAK 384 Matriptase 20601429   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
SPD 22728825