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|---|---|---|
| UniProt ID |
P78325 |
|
| Entry Name |
ADAM8_HUMAN |
|
| Protein Name |
Disintegrin and metalloproteinase domain-containing protein 8 |
|
| Primary Gene Name |
ADAM8 |
|
| Organism |
Homo sapiens (Human) |
|
| Molecular Function |
Hydrolase |
|
| Membrane Location |
Membrane |
|
|
|
|---|
| Substrate Name | ADAM8 | |
| Cell Type | ||
| Substrate Description | diverse cellular process regulated by proteolytic cleavage | |
| Substrate Function Category | enzyme | |
| Substrate Function Subtype | enzyme (protease) | |
| Sheddase | ADAM8 | |
| Shedding-related Disease | protease (metalloproteinase) | |
| Short Summary of Papers | autolytic processing of ADAM8 for proteolytic activity | |
| Cleavage Information | NONE | |
| PMID | 12372841 |
|
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|---|
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|---|---|---|
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Start | End |
|
|
17 | 655 |
|
|
656 | 676 |
|
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||||||||
|---|---|---|---|---|---|---|---|---|
| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| MEROPS | RETR*YVEL | 200 | PCSK7 peptidase | not physiologically relevant | consensus sequence | 18505722 | ||
| MEROPS | RETR*YVEL | 200 | PCSK5 peptidase | not physiologically relevant | consensus sequence | 18505722 | ||
| MEROPS | RETR*YVEL | 200 | PCSK6 peptidase | not physiologically relevant | consensus sequence | 18505722 | ||
| MEROPS | RETR*YVEL | 200 | PCSK4 peptidase | not physiologically relevant | consensus sequence | 18505722 | ||
| MEROPS | RETR*YVEL | 200 | PCSK2 peptidase | not physiologically relevant | consensus sequence | 18505722 | ||
| MEROPS | RETR*YVEL | 200 | furin | not physiologically relevant | consensus sequence | 18505722 | ||