UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

P58295
Entry Name

SC6A5_RAT
Protein Name

Sodium- and chloride-dependent glycine transporter 2
Primary Gene Name

Slc6a5
Organism

Rattus norvegicus (Rat)
Molecular Function

Membrane Location

Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name glycine transporter 2 (GlyT2)
Cell Type
Substrate Description terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals.
Substrate Function Category central nervous system (neuron)
Substrate Function Subtype
Sheddase calpain
Shedding-related Disease membrane transporters
Short Summary of Papers Ca2+-triggered proteolysis may contribute to the regulation of GlyT2 trafficking and/or function in the neuronal plasma membran
Cleavage Information ZNo-Human:
PMID 14675166



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Transmembrane
 		202 222
Transmembrane
 		230 249
Transmembrane
 		273 293
Extracellular
 		294 395
Transmembrane
 		396 414
Transmembrane
 		423 440
Transmembrane
 		476 493
Transmembrane
 		505 526
Transmembrane
 		559 578
Transmembrane
 		606 624
Transmembrane
 		640 660
Transmembrane
 		681 700
Transmembrane
 		719 737



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
PAPER WVNM*SQST 156 calpain 14675166   
PAPER VVLG*TDGI 164 calpain 14675166   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
NO_DATA NO_DATA NO_DATA