UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

P57739
Entry Name

CLD2_HUMAN
Protein Name

Claudin-2
Primary Gene Name

CLDN2
Organism

Homo sapiens (Human)
Molecular Function

Membrane Location

Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name claudin-2
Cell Type
Substrate Description tight junction,epithelial barrier function
Substrate Function Category cell surface structure
Substrate Function Subtype
Sheddase serine protease
Shedding-related Disease tight junction (cell junction)
Short Summary of Papers cleavage of the claudin-2 protein is involved in IFN-γ-mediated disruption of tight junction complexes to enhance epithelial permeability
Cleavage Information NONE
PMID 16232214 24665393



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Transmembrane
 		8 28
Extracellular
 		29 81
Transmembrane
 		82 102
Transmembrane
 		117 137
Extracellular
 		138 162
Transmembrane
 		163 183



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
PAPER No_information serine protease 16232214   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
NO_DATA NO_DATA NO_DATA