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| UniProt ID |
P57087 |
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| Entry Name |
JAM2_HUMAN |
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| Protein Name |
Junctional adhesion molecule B |
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| Primary Gene Name |
JAM2 |
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| Organism |
Homo sapiens (Human) |
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| Molecular Function | ||
| Membrane Location |
Cell membrane |
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| Substrate Name | JAM-B | |
| Cell Type | ||
| Substrate Description | may play a role in the processes of lymphocyte homing to secondary lymphoid organs. | |
| Substrate Function Category | Immune and Inflammation | |
| Substrate Function Subtype | ||
| Sheddase | cathepsin S | |
| Shedding-related Disease | cell adhesion molecule | |
| Short Summary of Papers | shedding of JAM-B leads to disruption of blood–brain barrier(BBB) integrity and thus facilitates breaching of the BBB by breast cancer cells. | |
| Cleavage Information | NONE | |
| PMID | 25367033 |
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Start | End |
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29 | 238 |
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239 | 259 |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| MEROPS | KAYG*FSAP | 28 | signal peptidase complex (animal) | physiologically relevant | N-terminal sequencing | 15340161 | ||
| PAPER | No_information | Cathepsin S | 25367033 | |||||
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| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| Sys-BodyFluid | Cerebrospinal fluid | 18052119 | |