UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

P56818
Entry Name

BACE1_MOUSE
Protein Name

Beta-secretase 1
Primary Gene Name

Bace1
Organism

Mus musculus (Mouse)
Molecular Function

Hydrolase
Protease
Aspartyl protease
Membrane Location

Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name BACE1
Cell Type
Substrate Description beta-secretase mediate proteolytic processing
Substrate Function Category enzyme
Substrate Function Subtype enzyme (protease)
Sheddase ADAM10
Shedding-related Disease protease (beta-secretase)
Short Summary of Papers shedding of BACE1 have no effect on amyloid precursor protein processing at the β-site
Cleavage Information NONE
PMID 12857759



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		22 457
Transmembrane
 		458 478



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
MEROPS RLPR*ETDE 45 furin physiologically relevant NONE 11071887   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
PAPER β-Cell 23430253