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| UniProt ID |
P56817 |
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| Entry Name |
BACE1_HUMAN |
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| Protein Name |
Beta-secretase 1 |
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| Primary Gene Name |
BACE1 |
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| Organism |
Homo sapiens (Human) |
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| Molecular Function |
Hydrolase |
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| Membrane Location |
Cell membrane |
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| Substrate Name | BACE1 | |
| Cell Type | ||
| Substrate Description | beta-secretase mediate proteolytic processing | |
| Substrate Function Category | enzyme | |
| Substrate Function Subtype | enzyme (protease) | |
| Sheddase | ADAM10 | |
| Shedding-related Disease | protease (beta-secretase) | |
| Short Summary of Papers | shedding of BACE1 have no effect on amyloid precursor protein processing at the β-site | |
| Cleavage Information | NONE | |
| PMID | 12857759 |
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Start | End |
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22 | 457 |
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458 | 478 |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| MEROPS | GTQH*GIRL | 24 | memapsin-2 | physiologically relevant | NONE | 10677483 | ||
| MEROPS | LGLR*LPRE | 42 | clostripain | not physiologically relevant | NONE | 11015226 | ||
| MEROPS | RLPR*ETDE | 45 | furin | not physiologically relevant | consensus sequence | 18505722 | ||
| MEROPS | RLPR*ETDE | 45 | PCSK2 peptidase | not physiologically relevant | consensus sequence | 18505722 | ||
| MEROPS | RLPR*ETDE | 45 | PCSK4 peptidase | not physiologically relevant | consensus sequence | 18505722 | ||
| MEROPS | RLPR*ETDE | 45 | PCSK6 peptidase | not physiologically relevant | consensus sequence | 18505722 | ||
| MEROPS | RLPR*ETDE | 45 | PCSK5 peptidase | not physiologically relevant | consensus sequence | 18505722 | ||
| MEROPS | RLPR*ETDE | 45 | memapsin-2 | physiologically relevant | N-terminal sequencing | 12204094 | ||
| MEROPS | RLPR*ETDE | 45 | kallikrein-related peptidase 4 | physiologically relevant | consensus sequence | 15389820 | ||
| MEROPS | RLPR*ETDE | 45 | PCSK7 peptidase | physiologically relevant | NONE | 11481238 | ||
| PMAP | RLPR*ETDE | 45 | furin | This entry is based on an experiment | N-terminal sequencing | 10887202 10956649 | ||
| HPRD | LPRE*TDEE | 46 | Furin | 10887202 | ||||
| HPRD | LPRE*TDEE | 46 | Furin | 10887202 | ||||
| HPRD | LPRE*TDEE | 46 | Furin | 10887202 | ||||
| HPRD | LPRE*TDEE | 46 | Furin | 10887202 | ||||
| MEROPS | PGRR*GSFV | 57 | clostripain | not physiologically relevant | NONE | 11015226 | ||
| MEROPS | SSNF*AVGA | 99 | memapsin-2 | physiologically relevant | NONE | 10677483 | ||
| MEROPS | GLAY*AEIA | 184 | memapsin-2 | physiologically relevant | NONE | 10677483 | ||
| PAPER | No_information | ADAM10 | 12857759 | |||||
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| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| NO_DATA | NO_DATA | NO_DATA | |