UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

P56677
Entry Name

ST14_MOUSE
Protein Name

Suppressor of tumorigenicity 14 protein homolog
Primary Gene Name

St14
Organism

Mus musculus (Mouse)
Molecular Function

Hydrolase
Protease
Serine protease
Membrane Location

Membrane



Biological Literature Report of Shedding
Substrate Name Epithin/PRSS14
Cell Type 427.1.86 cells
Substrate Description
Substrate Function Category
Substrate Function Subtype
Sheddase ADAM17
Shedding-related Disease
Short Summary of Papers TGF-β induces translocation of epithin/PRSS14 sheddase, TACE, which results in the shedding of epithin.
Cleavage Information
PMID 25245289 20652801



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Transmembrane
 		56 76
Extracellular
 		77 855



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
PAPER macrophage 24396086