UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

P55287
Entry Name

CAD11_HUMAN
Protein Name

Cadherin-11
Primary Gene Name

CDH11
Organism

Homo sapiens (Human)
Molecular Function

Membrane Location

Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name cadherin-11(CDH11)
Cell Type
Substrate Description homophilic adhesion. synovial development
Substrate Function Category Immune and Inflammation
Substrate Function Subtype
Sheddase metalloproteinase
Shedding-related Disease cell adhesion molecule
Short Summary of Papers cadherin-11 undergoes ectodomain shedding followed by regulated intramembrane proteolysis in synovial fibroblasts. cadherin-11 fragments were enriched in RA synovial fluid
Cleavage Information NONE
PMID 26312857



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		54 617
Transmembrane
 		618 640



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
PAPER NAEA*YILN 608 UNKNOWN Mass spectrometry 33796845   
PAPER No_information ADAM10 26312857   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
Sys-BodyFluid Urine 15529407
Sys-BodyFluid Urine 16335936
Sys-BodyFluid Urine 16281181
Sys-BodyFluid Urine 16948836
Sys-BodyFluid Plasma/Serum 14718574
Sys-BodyFluid Amniotic fluid 17495049
Sys-BodyFluid Saliva 18361515
HCSD cancer (lung cancer) 19776420
HCSD cancer(prostate cancer) 22908226
HCSD cancer(Head and neck squamous cell carcinoma) 23665456
HCSD cancer(colorectal cancer 22408128
HCSD cancer(ovarian cancer) 22623176