UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

P55085
Entry Name

PAR2_HUMAN
Protein Name

Proteinase-activated receptor 2
Primary Gene Name

F2RL1
Organism

Homo sapiens (Human)
Molecular Function

Receptor
G-protein coupled receptor
Transducer
Membrane Location

Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name proteinase-activated receptor-2 (PAR2)
Cell Type
Substrate Description G protein-coupled receptors (GPCRs) activated by proteolysis. receptor for trypsin and trypsin-like enzymes coupled to G proteins, modulation of inflammatory responses and regulation of innate and adaptive immunity
Substrate Function Category growth factor & growth hormone
Substrate Function Subtype
Sheddase neutrophil serine proteinases (elastase and cathepsin G)
Shedding-related Disease cell receptor (GPCR)
Short Summary of Papers neutrophil serine proteinases may play a role in PAR-2-mediated lung inflammation, preventing proteolytic-activation by trypsin
Cleavage Information NONE
PMID 12594060



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		37 71
Transmembrane
 		72 101
Transmembrane
 		109 137
Extracellular
 		138 149
Transmembrane
 		150 177
Transmembrane
 		184 211
Extracellular
 		212 235
Transmembrane
 		236 269
Transmembrane
 		278 317
Extracellular
 		318 323
Transmembrane
 		324 347



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
MEROPS GTNR*SSKG 31 kallikrein-related peptidase 5 physiologically relevant NONE 16885167   
MEROPS GTNR*SSKG 31 kallikrein-related peptidase 14 physiologically relevant NONE 16885167   
PMAP GTNR*SSKG 31 kallikrein hK14 This entry is based on an experiment Mass spectrometry 16885167   
PMAP GTNR*SSKG 31 kallikrein hK5 This entry is based on an experiment Mass spectrometry 16885167   
HPRD RSSK*GRSL 34 Plasminogen 10978167   
MEROPS RSSK*GRSL 34 trypsin 1 not physiologically relevant NONE 10978167   
MEROPS RSSK*GRSL 34 myeloblastin physiologically relevant Mass spectroscopy 12370398   
MEROPS RSSK*GRSL 34 plasmin physiologically relevant NONE 10978167   
PMAP RSSK*GRSL 34 plasmin This entry is based on an experiment 10978167   
HPRD SKGR*SLIG 36 Prothrombin; Plasminogen; 10978167    12604689    10978167    9020112   
MEROPS SKGR*SLIG 36 trypsin 1 not physiologically relevant NONE 10978167   
MEROPS SKGR*SLIG 36 rhodesain physiologically relevant consensus sequence 19621073   
MEROPS SKGR*SLIG 36 kallikrein-related peptidase 14 physiologically relevant NONE 16885167   
MEROPS SKGR*SLIG 36 peptidase 9 (Dermatophagoides-type) physiologically relevant NONE 11441110   
MEROPS SKGR*SLIG 36 cationic trypsin (Homo sapiens-type) physiologically relevant NONE 8615752   
MEROPS SKGR*SLIG 36 myeloblastin physiologically relevant Mass spectroscopy 12370398   
MEROPS SKGR*SLIG 36 tryptase alpha physiologically relevant NONE 9020112   
MEROPS SKGR*SLIG 36 thrombin physiologically relevant NONE 10978167   
MEROPS SKGR*SLIG 36 plasmin physiologically relevant NONE 10978167   
MEROPS SKGR*SLIG 36 peptidase 3 (Dermatophagoides-type) physiologically relevant NONE 11441110   
MEROPS SKGR*SLIG 36 kallikrein-related peptidase 6 physiologically relevant NONE 16885167   
MEROPS SKGR*SLIG 36 kallikrein-related peptidase 4 physiologically relevant consensus sequence 15389820   
MEROPS SKGR*SLIG 36 matriptase physiologically relevant NONE 17131055   
MEROPS SKGR*SLIG 36 unknown peptidase physiologically relevant NONE 18331590   
PMAP SKGR*SLIG 36 trypsin 1 This entry is based on an experiment Others 10671485   
PMAP SKGR*SLIG 36 tryptase alpha This entry is based on an experiment Mass spectrometry 9020112   
PMAP SKGR*SLIG 36 kallikrein hK14 This entry is based on an experiment Mass spectrometry 16885167   
PMAP SKGR*SLIG 36 kallikrein hK5 This entry is based on an experiment Mass spectrometry 16885167   
PMAP SKGR*SLIG 36 kallikrein hK6 This entry is based on an experiment Mass spectrometry 16885167   
PMAP SKGR*SLIG 36 plasmin This entry is based on an experiment 9020112   
PMAP SKGR*SLIG 36 plasmin This entry is based on an experiment 10978167   
PMAP SKGR*SLIG 36 plasmin This entry is based on an experiment 12604689   
PMAP SKGR*SLIG 36 cationic trypsin This entry is based on an experiment 8615752   
MEROPS KGRS*LIGK 37 pseudolysin not physiologically relevant NONE 15705968   
HPRD GRSL*IGKV 38 Cathepsin G 10978167   
MEROPS GRSL*IGKV 38 cathepsin G physiologically relevant NONE 10978167   
MEROPS LIGK*VDGT 41 trypsin 1 not physiologically relevant NONE 16885167   
MEROPS LIGK*VDGT 41 kallikrein-related peptidase 14 physiologically relevant NONE 16885167   
MEROPS LIGK*VDGT 41 myeloblastin physiologically relevant Mass spectroscopy 12370398   
MEROPS LIGK*VDGT 41 tryptase alpha physiologically relevant NONE 9020112   
MEROPS LIGK*VDGT 41 kallikrein-related peptidase 6 physiologically relevant NONE 16885167   
PMAP LIGK*VDGT 41 tryptase alpha This entry is based on an experiment Mass spectrometry 9020112   
PMAP LIGK*VDGT 41 kallikrein hK14 This entry is based on an experiment Mass spectrometry 16885167   
PMAP LIGK*VDGT 41 kallikrein hK6 This entry is based on an experiment Mass spectrometry 16885167   
HPRD IGKV*DGTS 42 Elastase, leukocyte 10978167   
MEROPS IGKV*DGTS 42 elastase-2 physiologically relevant NONE 10978167   
HPRD VDGT*SHVT 45 Calpain 2 10978167   
MEROPS VDGT*SHVT 45 calpain-2 not physiologically relevant NONE 10978167   
HPRD TSHV*TGKG 48 Elastase, leukocyte; Proteinase 3; 10978167   
MEROPS TSHV*TGKG 48 elastase-2 physiologically relevant NONE 10978167   
MEROPS TSHV*TGKG 48 myeloblastin physiologically relevant NONE 10978167   
PMAP TSHV*TGKG 48 myeloblastin This entry is based on an experiment 10978167   
HPRD VTGK*GVTV 51 10978167   
MEROPS VTGK*GVTV 51 trypsin 1 not physiologically relevant NONE 10978167   
MEROPS VTGK*GVTV 51 kallikrein-related peptidase 14 physiologically relevant NONE 16885167   
MEROPS VTGK*GVTV 51 kallikrein-related peptidase 6 physiologically relevant NONE 16885167   
PMAP VTGK*GVTV 51 trypsin 1 This entry is based on an experiment Mass spectrometry 16885167   
PMAP VTGK*GVTV 51 kallikrein hK14 This entry is based on an experiment Mass spectrometry 16885167   
PMAP VTGK*GVTV 51 kallikrein hK6 This entry is based on an experiment Mass spectrometry 16885167   
MEROPS TGKG*VTVE 52 pseudolysin not physiologically relevant NONE 15705968   
HPRD GKGV*TVET 53 Elastase, leukocyte 10978167   
MEROPS GKGV*TVET 53 elastase-2 physiologically relevant NONE 10978167   
HPRD GVTV*ETVF 55 Proteinase 3 10978167   
MEROPS GVTV*ETVF 55 myeloblastin physiologically relevant NONE 10978167   
HPRD TVET*VFSV 57 Proteinase 3 10978167   
MEROPS TVET*VFSV 57 myeloblastin physiologically relevant NONE 10978167   
HPRD VETV*FSVD 58 Elastase, leukocyte; Calpain 2; 10978167   
MEROPS VETV*FSVD 58 calpain-2 not physiologically relevant NONE 10978167   
MEROPS VETV*FSVD 58 elastase-2 physiologically relevant NONE 10978167   
HPRD ETVF*SVDE 59 Cathepsin G; Calpain, large polypeptide L1; 10978167   
MEROPS ETVF*SVDE 59 calpain-1 not physiologically relevant NONE 10978167   
MEROPS ETVF*SVDE 59 cathepsin G physiologically relevant NONE 10978167   
PMAP ETVF*SVDE 59 cathepsin G This entry is based on an experiment 10978167   
HPRD VFSV*DEFS 61 Proteinase 3 10978167   
MEROPS TVFSV*DEFS 61 myeloblastin physiologically relevant NONE 10978167   
HPRD FSVD*EFSA 62 Proteinase 3 10978167   
MEROPS FSVD*EFSA 62 myeloblastin physiologically relevant NONE 10978167   
HPRD VDEF*SASV 64 Cathepsin G 10978167   
MEROPS VDEF*SASV 64 cathepsin G physiologically relevant NONE 10978167   
PMAP VDEF*SASV 64 cathepsin G This entry is based on an experiment 10978167   
HPRD VLTG*KLTT 71 Calpain 2 10978167   
MEROPS VLTG*KLTT 71 calpain-2 not physiologically relevant NONE 10978167   
HPRD LTGK*LTTV 72 Proteinase 3 10978167   
MEROPS LTGK*LTTV 72 trypsin 1 not physiologically relevant NONE 10978167   
MEROPS LTGK*LTTV 72 myeloblastin physiologically relevant NONE 10978167   
HPRD GKLT*TVFL 74 Elastase, leukocyte; Proteinase 3; 10978167   
MEROPS GKLT*TVFL 74 elastase-2 physiologically relevant NONE 10978167   
MEROPS GKLT*TVFL 74 myeloblastin physiologically relevant NONE 10978167   
PMAP GKLT*TVFL 74 myeloblastin This entry is based on an experiment 10978167   
HPRD KLTT*VFLP 75 Proteinase 3 10978167   
MEROPS KLTT*VFLP 75 myeloblastin physiologically relevant NONE 10978167   
PMAP KLTT*VFLP 75 myeloblastin This entry is based on an experiment 10978167   
HPRD LTTV*FLPI 76 Elastase, leukocyte; Proteinase 3; 10978167   
MEROPS LTTV*FLPI 76 elastase-2 physiologically relevant NONE 10978167   
MEROPS LTTV*FLPI 76 myeloblastin physiologically relevant NONE 10978167   
PMAP LTTV*FLPI 76 myeloblastin This entry is based on an experiment 10978167   
PAPER No_information neutrophil serine proteinases 12594060   
PMAP No_information myeloblastin This entry is a predicted 12370398   
PMAP No_information gingipain R This entry is based on an experiment Gel electrophoresis 15470061   
PMAP No_information gingipain K This entry is based on an experiment Gel electrophoresis 15470061   
PMAP No_information coagulation factor Xa This entry is based on an experiment 11438726   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
NO_DATA NO_DATA NO_DATA