UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

P54760
Entry Name

EPHB4_HUMAN
Protein Name

Ephrin type-B receptor 4
Primary Gene Name

EPHB4
Organism

Homo sapiens (Human)
Molecular Function

Tyrosine-protein kinase
Developmental protein
Transferase
Kinase
Receptor
Membrane Location

Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name Ephrin receptor B4
Cell Type
Substrate Description
Substrate Function Category
Substrate Function Subtype
Sheddase ADAM9
Shedding-related Disease cancer
Short Summary of Papers selective compounds that inhibited ADAM9 are found
Cleavage Information
PMID 28264989



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		16 539
Transmembrane
 		540 560



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
MEROPS LAAA*LEET 15 unknown peptidase physiologically relevant Mass spectroscopy 26796116   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
Sys-BodyFluid Plasma/Serum 16878292
Sys-BodyFluid Plasma/Serum 16104056
Sys-BodyFluid Plasma/Serum 17081049
Sys-BodyFluid Plasma/Serum 17553692
Sys-BodyFluid Urine 16948836
HCSD cancer(prostate cancer) 22908226
HCSD cancer(23 cancer cell lines) 20124221
HCSD cancer(Head and neck squamous cell carcinoma) 23665456
HCSD cancer(colon tumor) 23684732
HCSD cancer(colorectal carsinoma) 23585443
HCSD cancer(colorectal cancer 24418523
HCSD cancer(pancreatic cancer) 21625447
HCSD cancer(ovarian cancer) 23805888
HCSD cancer(oral cancer ) 21714544
HCSD cancer(Liver metastasis in colorectal cancer) 23443137