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| UniProt ID |
P51693 |
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| Entry Name |
APLP1_HUMAN |
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| Protein Name |
Amyloid-like protein 1 |
|
| Primary Gene Name |
APLP1 |
|
| Organism |
Homo sapiens (Human) |
|
| Molecular Function |
Heparin-binding |
|
| Membrane Location |
Cell membrane |
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|---|
| Substrate Name | amyloid precursor protein-like protein 1(APLP1) | |
| Cell Type | ||
| Substrate Description | synaptogenesis, postsynaptic function | |
| Substrate Function Category | central nervous system (neuron) | |
| Substrate Function Subtype | ||
| Sheddase | (unknown) | |
| Shedding-related Disease | Integral membrane protein | |
| Short Summary of Papers | the APLP1 are subjected to RIP (regulated intramembrane proteolysis) by γ-secretase after ectodomain shedding | |
| Cleavage Information | NONE | |
| PMID | 9428684 12228233 |
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Start | End |
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39 | 580 |
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581 | 603 |
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|---|---|---|---|---|---|---|---|---|
| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| PAPER | PAIG*SLAG | 38 | UNKNOWN | Mass spectrometry | 33796845 | |||
| MEROPS | VEVD*PMLT | 620 | caspase-3 | physiologically relevant | NONE | 12124429 | ||
| PAPER | No_information | (unkown) | 9428684 | |||||
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|---|---|---|---|
| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| Sys-BodyFluid | Cerebrospinal fluid | 17853512 | |
| Sys-BodyFluid | Cerebrospinal fluid | 18052119 | |
| Sys-BodyFluid | Cerebrospinal fluid | 17022648 | |
| Sys-BodyFluid | Cerebrospinal fluid | 15952730 | |
| Sys-BodyFluid | Cerebrospinal fluid | 15582749 | |
| Sys-BodyFluid | Cerebrospinal fluid | 14998169 | |
| Sys-BodyFluid | Plasma/Serum | 17553692 | |
| HCSD | cancer (lung cancer) | 19776420 | |
| HCSD | cancer(prostate cancer) | 22908226 | |
| HCSD | cancer(23 cancer cell lines) | 20124221 | |
| HCSD | non-small cell lung cancer | 21262398 | |
| locate | 17986452 | ||