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| UniProt ID |
P51654 |
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| Entry Name |
GPC3_HUMAN |
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| Protein Name |
Glypican-3 |
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| Primary Gene Name |
GPC3 |
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| Organism |
Homo sapiens (Human) |
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| Molecular Function |
Protease inhibitor |
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| Membrane Location |
Cell membrane |
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| Substrate Name | glypican-3 (GPC3) | |
| Cell Type | ||
| Substrate Description | cell surface proteoglycan that bears heparan sulfate. may be involved in the suppression/modulation of growth in the predominantly mesodermal tissues and organs. | |
| Substrate Function Category | disease; cell surface structure | |
| Substrate Function Subtype | ||
| Sheddase | proprotein convertase | |
| Shedding-related Disease | cancer; proteoglycan | |
| Short Summary of Papers | cleavage of glypican-3 by proprotein convertase is required for glypican-3 modulation of cell survival, Wnt signaling, and gastrulation movements.; the cleaved soluble NH2-terminal fragment of glypican-3 as a serological marker for early-stage hepatocellular carcinoma. | |
| Cleavage Information | GPI-anchor | |
| PMID | 15665316 14610063 |
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Start | End |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| PAPER | RQYR*SAYY | 358 | proprotein convertase | mutation | 15665316 14610063 | |||
| ASCENT | LKVA*HVEH | 376 | UNKNOWN | subtiligase-based N-terminal sequencing | 33536314 | |||
| ASCENT | LKVA*HVEH | 376 | UNKNOWN | subtiligase-based N-terminal sequencing | 33536314 | |||
| ASCENT | LKVA*HVEH | 376 | UNKNOWN | subtiligase-based N-terminal sequencing | ||||
| MEROPS | VLDK*NLDE | 486 | lysyl endopeptidase (bacteria) | not physiologically relevant | Mass spectroscopy | NONE | ||
| MEROPS | GMIK*VKNQ | 515 | lysyl endopeptidase (bacteria) | not physiologically relevant | Mass spectroscopy | NONE | ||
| ASCENT | LAEL*AYDL | 526 | UNKNOWN | subtiligase-based N-terminal sequencing | 33536314 | |||
| PAPER | ELAY*DLDV | 528 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | GNSQ*QATP | 540 | UNKNOWN | Mass spectrometry | 33796845 | |||
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| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| SPD | 22728825 | ||
| Sys-BodyFluid | Urine | 16948836 | |
| Sys-BodyFluid | Plasma/Serum | 12917320 | |
| Sys-BodyFluid | Plasma/Serum | 14718574 | |
| HCSD | cancer(prostate cancer) | 22908226 | |
| HCSD | cancer(23 cancer cell lines) | 20124221 | |
| HCSD | cancer(colorectal cancer | 24418523 | |
| HCSD | cancer(non small cell lung cancer) | 19655816 | |
| locate | 17986452 | ||