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| UniProt ID |
P50895 |
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| Entry Name |
BCAM_HUMAN |
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| Protein Name |
Basal cell adhesion molecule |
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| Primary Gene Name |
BCAM |
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| Organism |
Homo sapiens (Human) |
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| Molecular Function |
Receptor |
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| Membrane Location |
Membrane |
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| Substrate Name | Lutheran (Lu,B-CAM) | |
| Cell Type | ||
| Substrate Description | laminin alpha-5 receptor. may mediate intracellular signaling. | |
| Substrate Function Category | disease | |
| Substrate Function Subtype | ||
| Sheddase | MT1-MMP | |
| Shedding-related Disease | cancer (hepatocellular carcinoma) | |
| Short Summary of Papers | soluble Lutheran/basal cell adhesion molecule is detectable in plasma of hepatocellular carcinoma patients and modulates cellular interaction with laminin-511. | |
| Cleavage Information | NONE | |
| PMID | 25051049 |
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Start | End |
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32 | 547 |
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548 | 568 |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| MEROPS | DAQA*EVRL | 31 | signal peptidase complex (animal) | physiologically relevant | N-terminal sequencing | 7777537 | ||
| PAPER | LICS*ARGH | 474 | UNKNOWN | Mass spectrometry | 33796845 | |||
| MEROPS | NPHG*NKRH | 529 | membrane-type matrix metallopeptidase-1 | physiologically relevant | Mass spectroscopy | 19667067 | ||
| MEROPS | PHGN*KRHV | 530 | granzyme B (Homo sapiens-type) | physiologically relevant | Mass spectroscopy | 18836177 | ||
| PAPER | No_information | MT1-MMP | 25051049 | |||||
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|---|---|---|---|
| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| Sys-BodyFluid | Seminal Fluid | 16709260 | |
| Sys-BodyFluid | Urine | 16948836 | |
| HCSD | cancer (gastric cancer) | 23161554 | |
| HCSD | cancer(prostate cancer) | 22908226 | |
| HCSD | cancer(23 cancer cell lines) | 20124221 | |
| HCSD | cancer(Head and neck squamous cell carcinoma) | 23665456 | |
| HCSD | cancer(colorectal cancer | 24418523 | |
| HCSD | cancer(head and neck squamous cell carcinoma) | 22918226 | |
| HCSD | cancer(urothelial carcinoma) | 23591195 | |
| HCSD | cancer(glioblastoma multiforme) | 21574646 | |
| HCSD | cancer(pancreatic cancer) | 21625447 | |
| HCSD | cancer(ovarian cancer) | 23805888 | |
| HCSD | cancer(ovarian cancer) | 22623176 | |
| HCSD | cancer(oral cancer ) | 21714544 | |
| HCSD | non-small cell lung cancer | 21262398 | |
| HCSD | cancer(non small cell lung cancer) | 19655816 | |
| HCSD | cancer(colorectal cancer) | 24681409 | |
| HCSD | cancer(lung adenocarcinoma) | 22896658 | |