UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

P50593
Entry Name

GPC1_CHICK
Protein Name

Glypican-1
Primary Gene Name

GPC1
Organism

Gallus gallus (Chicken)
Molecular Function

Membrane Location

Secreted
Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name glypican-1
Cell Type
Substrate Description involved in fibroblast growth factor 2 (FGF2) signal transduction
Substrate Function Category cell surface structure
Substrate Function Subtype proteoglycan (heparan sulfate) - GPI-anchor cell membrane
Sheddase (unkown),
Shedding-related Disease proteoglycan
Short Summary of Papers shed form of glypican-1 may be incorporated into the ECM and sequester FGF2 away from its receptor during muscle differentiation
Cleavage Information (GPI-anchor)ZNo human: P35052
PMID 20008810



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
NO_INFO



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
MEROPS PARG*DSGS 20 unknown peptidase physiologically relevant Mass spectroscopy 26796116   
MEROPS GVIG*ASSR 524 unknown peptidase physiologically relevant Mass spectroscopy 26796116   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
NO_DATA NO_DATA NO_DATA