UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

P50281
Entry Name

MMP14_HUMAN
Protein Name

Matrix metalloproteinase-14
Primary Gene Name

MMP14
Organism

Homo sapiens (Human)
Molecular Function

Hydrolase
Protease
Metalloprotease
Membrane Location

Membrane



Biological Literature Report of Shedding
Substrate Name MT-MMP1 (MMP14)
Cell Type
Substrate Description metalloproteinase mediate ectodomain shedding
Substrate Function Category enzyme
Substrate Function Subtype enzyme (protease)
Sheddase MT-MMP1 (MMP14)
Shedding-related Disease protease
Short Summary of Papers shedding of MT1-MMP results in the release of a soluble inactive fragment , regulate MT1-MMP activity
Cleavage Information NONE
PMID 15137052



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		112 541
Transmembrane
 		542 562



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
MEROPS PPGD*LRTH 49 matrix metallopeptidase-2 physiologically relevant NONE 17938169   
MEROPS PPGD*LRTH 49 membrane-type matrix metallopeptidase-1 physiologically relevant NONE 17938169   
MEROPS SPQS*LSAA 60 matrix metallopeptidase-2 physiologically relevant NONE 17938169   
MEROPS SPQS*LSAA 60 membrane-type matrix metallopeptidase-1 physiologically relevant NONE 17938169   
MEROPS QVTG*KADA 78 peptidyl-Lys metallopeptidase not physiologically relevant Mass spectroscopy NONE   
MEROPS GAEI*KANV 103 peptidyl-Lys metallopeptidase not physiologically relevant Mass spectroscopy NONE   
MEROPS ANVR*RKRY 108 plasmin physiologically relevant NONE 9037191   
MEROPS RRKR*YAIQ 111 metallopeptidase II (Bacteroides fragilis) not physiologically relevant NONE NONE   
MEROPS RRKR*YAIQ 111 PCSK2 peptidase not physiologically relevant consensus sequence 18505722   
MEROPS RRKR*YAIQ 111 PCSK4 peptidase not physiologically relevant consensus sequence 18505722   
MEROPS RRKR*YAIQ 111 PCSK6 peptidase not physiologically relevant consensus sequence 18505722   
MEROPS RRKR*YAIQ 111 PCSK5 peptidase not physiologically relevant consensus sequence 18505722   
MEROPS RRKR*YAIQ 111 PCSK7 peptidase not physiologically relevant consensus sequence 18505722   
MEROPS RRKR*YAIQ 111 membrane-type matrix metallopeptidase-1 physiologically relevant NONE 12514192   
MEROPS RRKR*YAIQ 111 plasmin physiologically relevant NONE 9037191   
MEROPS RRKR*YAIQ 111 furin physiologically relevant NONE 8804434   
MEROPS QGLK*WQHN 118 membrane-type matrix metallopeptidase-1 physiologically relevant NONE 12514192   
MEROPS FCIQ*NYTP 129 membrane-type matrix metallopeptidase-1 physiologically relevant NONE 12514192   
MEROPS AEPW*TVRN 221 membrane-type matrix metallopeptidase-1 physiologically relevant NONE 12514192   
MEROPS DPSA*IMAP 255 membrane-type matrix metallopeptidase-1 physiologically relevant NONE 12004057   
MEROPS QQLY*GGES 283 membrane-type matrix metallopeptidase-1 physiologically relevant NONE 12514192   
MEROPS QLYG*GESG 284 membrane-type matrix metallopeptidase-1 physiologically relevant NONE NONE   
MEROPS PQPR*TTSR 298 membrane-type matrix metallopeptidase-1 physiologically relevant NONE 12514192   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
Sys-BodyFluid Seminal Fluid 16709260
Sys-BodyFluid Plasma/Serum 16104056
Sys-BodyFluid Plasma/Serum 14718574
HCSD cancer(prostate cancer) 22908226
HCSD cancer(23 cancer cell lines) 20124221
HCSD cancer(Head and neck squamous cell carcinoma) 23665456
HCSD cancer(colorectal cancer 22408128
HCSD cancer(colorectal cancer 24418523
HCSD cancer(head and neck squamous cell carcinoma) 22918226
HCSD cancer(urothelial carcinoma) 23591195
HCSD cancer(glioblastoma multiforme) 21574646
HCSD cancer(ovarian cancer) 23805888
HCSD cancer(oral cancer ) 21714544
HCSD cancer(Liver metastasis in colorectal cancer) 23443137
HCSD cancer(non small cell lung cancer) 19655816
locate 17986452