UniProt Summary
UniProt ID

P48960

Entry Name

AGRE5_HUMAN

Protein Name

Adhesion G protein-coupled receptor E5

Primary Gene Name

ADGRE5

Organism

Homo sapiens (Human)

Molecular Function

Receptor
G-protein coupled receptor
Transducer

Membrane Location

Secreted
Cell membrane
Membrane




Biological Literature Report of Shedding
Substrate Name Adhesion-G protein-coupled receptor CD97(CD97,ADGRE5)
Cell Type
Substrate Description adhesion-class G protein-coupled receptor , leukocyte activation
Substrate Function Category Immune and Inflammation
Substrate Function Subtype
Sheddase (unkown)
Shedding-related Disease cell receptor (GPCR)
Short Summary of Papers the shedding of the CD97 α-chain induced by CD55 may regulate CD97-CD55-mediated cell adhesion. the shed ectodomains can act as a potent chemoattractant for human endothelial cells and as a proangiogenic factor
Cleavage Information NONE
PMID 15576472 23447688



Cleavage Site Diagram



Topological Domains
Topological Domains
Start End
Extracellular
21 552
Transmembrane
553 572
Transmembrane
582 601
Extracellular
602 620
Transmembrane
621 642
Transmembrane
654 674
Extracellular
675 691
Transmembrane
692 712
Transmembrane
740 760
Extracellular
761 766
Transmembrane
767 789



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
PAPER No_information (unkown) 8955192    10211878   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
Sys-BodyFluid Plasma/Serum 17553692
HCSD cancer(prostate cancer) 22908226
HCSD cancer(Liver metastasis in colorectal cancer) 23443137
locate 17986452