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| UniProt ID |
P48551 |
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| Entry Name |
INAR2_HUMAN |
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| Protein Name |
Interferon alpha/beta receptor 2 |
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| Primary Gene Name |
IFNAR2 |
|
| Organism |
Homo sapiens (Human) |
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| Molecular Function |
Receptor |
|
| Membrane Location |
Secreted |
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|---|
| Substrate Name | IFNAR2 | |
| Cell Type | ||
| Substrate Description | associates with IFNAR1 to form the type I interferon receptor. receptor for interferons alpha and beta. | |
| Substrate Function Category | Immune and Inflammation | |
| Substrate Function Subtype | ||
| Sheddase | ADAM17 | |
| Shedding-related Disease | cytokine receptor | |
| Short Summary of Papers | the IFNAR2 are subjected to RIP (regulated intramembrane proteolysis) after ectodomain shedding by ADAM17 | |
| Cleavage Information | NONE | |
| PMID | 15286706 |
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Start | End |
|
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27 | 243 |
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244 | 264 |
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|---|---|---|---|---|---|---|---|---|
| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| PAPER | LKCT*LLPP | 228 | ADAM9 | NONE | NONE | 26554003 | ||
| PAPER | No_information | ADAM17 | 15286706 | |||||
| PMAP | No_information | NONE | This entry is based on an experiment | Gel electrophoresis | 15717316 15286706 | |||
| PMAP | No_information | NONE | This entry is based on an experiment | Gel electrophoresis | 15717316 15286706 | |||