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| UniProt ID |
P48357 |
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| Entry Name |
LEPR_HUMAN |
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| Protein Name |
Leptin receptor |
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| Primary Gene Name |
LEPR |
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| Organism |
Homo sapiens (Human) |
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| Molecular Function |
Receptor |
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| Membrane Location |
Secreted |
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| Substrate Name | leptin receptor(ObR) | |
| Cell Type | ||
| Substrate Description | receptor for hormone LEP/leptin. mediates LEP central and peripheral effects through the activation of different signaling pathways. | |
| Substrate Function Category | Immune and Inflammation | |
| Substrate Function Subtype | ||
| Sheddase | metalloprotease | |
| Shedding-related Disease | cytokine receptor | |
| Short Summary of Papers | soluble receptor or leptin binding protein (LBP), circulating in complex with leptin, is generated by proteolytic cleavage of membrane-anchored leptin receptor by a metalloprotease. | |
| Cleavage Information | NONE | |
| PMID | 11564702 |
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Start | End |
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22 | 839 |
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840 | 862 |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| PAPER | No_information | metalloprotease | 11564702 | |||||