UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

P48044
Entry Name

V2R_BOVIN
Protein Name

Vasopressin V2 receptor
Primary Gene Name

AVPR2
Organism

Bos taurus (Bovine)
Molecular Function

Receptor
G-protein coupled receptor
Transducer
Membrane Location

Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name vasopressin V2 receptor
Cell Type
Substrate Description G protein-coupled receptor. receptor for arginine vasopressin. involved in renal water reabsorption
Substrate Function Category growth factor & growth hormone
Substrate Function Subtype
Sheddase metalloproteinase
Shedding-related Disease cell receptor (GPCR)
Short Summary of Papers proteolytic cleavage of renal V2 vasopressin receptor by a metalloendopeptidase lead to a loss of ligand binding properties. the cleavage mediated by metalloendopeptidase may regulate V2 receptor function.
Cleavage Information ZNo-Human:
PMID 7896781



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		1 38
Transmembrane
 		39 63
Transmembrane
 		78 98
Extracellular
 		99 113
Transmembrane
 		114 135
Transmembrane
 		160 180
Extracellular
 		181 199
Transmembrane
 		200 219
Transmembrane
 		271 292
Extracellular
 		293 307
Transmembrane
 		308 327



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
PAPER ALFQ*VLPQ 92 metalloproteinase 7896781   
PAPER No_information metalloproteinase 7896781   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
NO_DATA NO_DATA NO_DATA