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|---|---|---|
| UniProt ID |
P48030 |
|
| Entry Name |
TGFA_MOUSE |
|
| Protein Name |
Protransforming growth factor alpha [Cleaved into: Transforming growth factor alpha |
|
| Primary Gene Name |
Tgfa |
|
| Organism |
Mus musculus (Mouse) |
|
| Molecular Function |
Mitogen |
|
| Membrane Location |
Secreted |
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| Substrate Name | TGF-α | |
| Cell Type | human colon carcinoma cell | |
| Substrate Description | ||
| Substrate Function Category | disease | |
| Substrate Function Subtype | Disease: Cancers (colon carcinoma) | |
| Sheddase | unkown | |
| Shedding-related Disease | cancer (colon carcinoma) | |
| Short Summary of Papers | defective shedding of mTGF-α enhanced activation of the EGFR in malignant cells | |
| Cleavage Information | NONE | |
| PMID | 10773880 |
| Substrate Name | TGF-α | |
| Cell Type | human peripheral blood mononuclear cells (hPBMCs) | |
| Substrate Description | EGFR signaling, various signals in cell proliferation, survival and migration | |
| Substrate Function Category | growth factor & growth hormone | |
| Substrate Function Subtype | growth factor (EGFR) | |
| Sheddase | ADAM10 | |
| Shedding-related Disease | growth factor (EGFR) | |
| Short Summary of Papers | shedding derived soluble EGF family growth factors, and transactivation of EGFR | |
| Cleavage Information | NONE | |
| PMID | 12590602 |
| Substrate Name | TGF-α | |
| Cell Type | gastric mucosal cells | |
| Substrate Description | ||
| Substrate Function Category | disease | |
| Substrate Function Subtype | Disease: gastric mucosa Infection by H. pylori trigger inflammatory responses | |
| Sheddase | ADAM17 | |
| Shedding-related Disease | gastric mucosa Infection by H. pylori | |
| Short Summary of Papers | H. pylori LPS-induced TGF-α ectodomain shedding and EGFR transactivation | |
| Cleavage Information | NONE | |
| PMID | 26658844 |
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|---|---|---|
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Start | End |
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24 | 97 |
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98 | 123 |
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|---|---|---|---|---|---|---|---|---|
| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| PAPER | AASQ*KKQA | 94 | metalloprotease,ADAM17 | NONE | 16542157 | |||
| PAPER | ASQK*KQAI | 95 | metalloprotease,ADAM17 | NONE | 16542157 | |||
| PMAP | No_information | ADAM17 peptidase | This_entry_is_based_on_an_experiment. | 14993236 | ||||
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|---|---|---|---|
| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| NO_DATA | NO_DATA | NO_DATA | |