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| UniProt ID |
P46531 |
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| Entry Name |
NOTC1_HUMAN |
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| Protein Name |
Neurogenic locus notch homolog protein 1 |
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| Primary Gene Name |
NOTCH1 |
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| Organism |
Homo sapiens (Human) |
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| Molecular Function |
Activator |
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| Membrane Location |
Cell membrane |
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| Substrate Name | Notch1 | |
| Cell Type | Jurkat and C12D cells | |
| Substrate Description | cell fate and development | |
| Substrate Function Category | central nervous system (neuron) | |
| Substrate Function Subtype | Central nervous system (CNS) pathology; receptor | |
| Sheddase | ADAM17 | |
| Shedding-related Disease | cell receptor | |
| Short Summary of Papers | ectodomain shedding result in RIP (regulated intramembrane proteolysis) and transcriptional activation of target genes | |
| Cleavage Information | NONE | |
| PMID | 10882063 18951988 |
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Start | End |
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19 | 1735 |
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1736 | 1756 |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| HPRD | RRRR*ELDP | 1664 | Furin | 9653148 | ||||
| MEROPS | RRRR*ELDP | 1664 | PCSK5 peptidase | not physiologically relevant | consensus sequence | 18505722 | ||
| MEROPS | RRRR*ELDP | 1664 | PCSK6 peptidase | not physiologically relevant | consensus sequence | 18505722 | ||
| MEROPS | RRRR*ELDP | 1664 | PCSK4 peptidase | not physiologically relevant | consensus sequence | 18505722 | ||
| MEROPS | RRRR*ELDP | 1664 | PCSK7 peptidase | not physiologically relevant | consensus sequence | 18505722 | ||
| MEROPS | RRRR*ELDP | 1664 | PCSK2 peptidase | not physiologically relevant | consensus sequence | 18505722 | ||
| HPRD | KIEA*VQSE | 1720 | ADAM 17 | 10882063 11518718 | ||||
| HPRD | VGCG*VLLS | 1753 | ADAM 17 | 10882063 9620803 | ||||
| MEROPS | VGCG*VLLS | 1753 | ADAM17 peptidase | physiologically relevant | NONE | 9620803 | ||
| MEROPS | VGCG*VLLS | 1753 | presenilin 1 | physiologically relevant | NONE | 11741961 | ||
| MEROPS | GVLL*SRKR | 1756 | memapsin-1 | physiologically relevant | Mass spectroscopy | 12423367 | ||
| MEROPS | VLLS*RKRR | 1757 | memapsin-1 | physiologically relevant | Mass spectroscopy | 12423367 | ||
| MEROPS | VLPD*LDDQ | 1833 | granzyme B (Homo sapiens-type) | physiologically relevant | consensus sequence | 16798735 | ||
| MEROPS | DQTD*HRQW | 1839 | caspase-3 | physiologically relevant | NONE | 15650752 | ||
| MEROPS | VDAD*CMDV | 1870 | granzyme B (Homo sapiens-type) | physiologically relevant | consensus sequence | 16798735 | ||
| MEROPS | DCMD*VNVR | 1873 | caspase-6 | physiologically relevant | NONE | 15650752 | ||
| MEROPS | EEED*APAV | 1905 | caspase-6 | physiologically relevant | NONE | 15650752 | ||
| MEROPS | VISD*FIYQ | 1912 | granzyme B (Homo sapiens-type) | physiologically relevant | consensus sequence | 16798735 | ||
| MEROPS | VSAD*AQGV | 1972 | granzyme B (Homo sapiens-type) | physiologically relevant | consensus sequence | 16798735 | ||
| MEROPS | VLLD*HFAN | 2082 | granzyme B (Homo sapiens-type) | physiologically relevant | consensus sequence | 16798735 | ||
| MEROPS | DHMD*RLPR | 2094 | caspase-6 | physiologically relevant | NONE | 15650752 | ||
| MEROPS | CLLD*SSGM | 2192 | caspase-6 | physiologically relevant | NONE | 15650752 | ||
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| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| SPD | 22728825 | ||
| Sys-BodyFluid | Plasma/Serum | 14718574 | |
| Sys-BodyFluid | Plasma/Serum | 17553692 | |
| Sys-BodyFluid | Plasma/Serum | 12917320 | |
| Sys-BodyFluid | Plasma/Serum | 16878292 | |
| Sys-BodyFluid | Urine | 16948836 | |
| HCSD | cancer(prostate cancer) | 22908226 | |
| HCSD | cancer(23 cancer cell lines) | 20124221 | |
| HCSD | cancer(colorectal cancer | 24418523 | |
| HCSD | cancer(Liver metastasis in colorectal cancer) | 23443137 | |