UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

P43121
Entry Name

MUC18_HUMAN
Protein Name

Cell surface glycoprotein MUC18
Primary Gene Name

MCAM
Organism

Homo sapiens (Human)
Molecular Function

Membrane Location

Membrane



Biological Literature Report of Shedding
Substrate Name MCAM(CD146)
Cell Type
Substrate Description cell adhesion, cell-cell cohesion and permeability at interendothelial junction.
Substrate Function Category Immune and Inflammation
Substrate Function Subtype
Sheddase metalloproteinase
Shedding-related Disease cell adhesion molecule
Short Summary of Papers TNFα icreases CD146 shedding by metalloproteinase. both the membrane and soluble form (sCD146) are involved in monocyte transmigration through the endothelial monolayer.
Cleavage Information NONE
PMID 19229070



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		24 559
Transmembrane
 		560 583



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
PAPER RVAG*VPGE 23 UNKNOWN Mass spectrometry 33796845   
PAPER AGVP*GEAE 25 UNKNOWN Mass spectrometry 33796845   
PAPER No_information metalloproteinase 19229070   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
Sys-BodyFluid Cerebrospinal fluid 18052119
Sys-BodyFluid Cerebrospinal fluid 17022648
Sys-BodyFluid Urine 16948836
Sys-BodyFluid Plasma/Serum 18793429
Sys-BodyFluid Plasma/Serum 18795103
Sys-BodyFluid Plasma/Serum 16104056
Sys-BodyFluid Plasma/Serum 17553692
HCSD cancer (lung cancer) 19776420
HCSD cancer(prostate cancer) 22908226
HCSD cancer(23 cancer cell lines) 20124221
HCSD cancer(Head and neck squamous cell carcinoma) 23665456
HCSD cancer(colorectal cancer 22408128
HCSD cancer(colorectal cancer 24418523
HCSD cancer(ovarian cancer) 22623176