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|---|---|---|
| UniProt ID |
P42892 |
|
| Entry Name |
ECE1_HUMAN |
|
| Protein Name |
Endothelin-converting enzyme 1 |
|
| Primary Gene Name |
ECE1 |
|
| Organism |
Homo sapiens (Human) |
|
| Molecular Function |
Hydrolase |
|
| Membrane Location |
Cell membrane |
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|---|
| Substrate Name | endothelin converting enzyme-1 (ECE-1) | |
| Cell Type | ||
| Substrate Description | converts big endothelin-1 to endothelin-1 | |
| Substrate Function Category | enzyme | |
| Substrate Function Subtype | ||
| Sheddase | (unknown) | |
| Shedding-related Disease | peptidase | |
| Short Summary of Papers | ECE-1 is shed from the surface suggest the potential for the use of circulating ECE-1 as a diagnostic or prognostic marker of pathological conditions such as cardiovascular diseases. | |
| Cleavage Information | NONE | |
| PMID | 17761169 |
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|---|---|---|
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Start | End |
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69 | 89 |
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90 | 770 |
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|---|---|---|---|---|---|---|---|---|
| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| PAPER | No_information | (unknown) | 17761169 | |||||
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|---|---|---|---|
| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| Sys-BodyFluid | Plasma/Serum | 14718574 | |
| Sys-BodyFluid | Plasma/Serum | 12917320 | |
| Sys-BodyFluid | Plasma/Serum | 16104056 | |
| HCSD | cancer(prostate cancer) | 22908226 | |
| HCSD | cancer(23 cancer cell lines) | 20124221 | |
| HCSD | cancer(Head and neck squamous cell carcinoma) | 23665456 | |
| HCSD | cancer(pancreatic cancer) | 21625447 | |
| HCSD | cancer(ovarian cancer) | 23805888 | |
| HCSD | cancer(Liver metastasis in colorectal cancer) | 23443137 | |
| HCSD | cancer(non small cell lung cancer) | 19655816 | |