UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

P42263
Entry Name

GRIA3_HUMAN
Protein Name

Glutamate receptor 3
Primary Gene Name

GRIA3
Organism

Homo sapiens (Human)
Molecular Function

Ion channel
Receptor
Ligand-gated ion channel
Membrane Location

Postsynaptic cell membrane
Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name Glutamate receptor 3 (GluR3)
Cell Type
Substrate Description receptor for glutamate that functions as ligand-gated ion channel in the central nervous system
Substrate Function Category central nervous system (neuron)
Substrate Function Subtype
Sheddase granzyme B
Shedding-related Disease cell receptor
Short Summary of Papers upon TCR-activation, the GluR3B peptide was cleavaged and release to the extracellular milieu from normal human T Cells
Cleavage Information NONE
PMID 17202328



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		29 552
Transmembrane
 		553 573
Transmembrane
 		628 648
Extracellular
 		649 823
Transmembrane
 		824 844



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
HPRD ISND*SASS 416 Granzyme B 11160179   
HPRD ISND*SASS 416 Granzyme B 11160179   
MEROPS ISND*SASS 416 granzyme B (Homo sapiens-type) physiologically relevant mutation 11160179   
MEROPS ISND*SASS 416 granzyme B (Homo sapiens-type) physiologically relevant mutation 11160179   
PAPER No_information granzyme B 17202328   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
NO_DATA NO_DATA NO_DATA