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| UniProt ID |
P41273 |
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| Entry Name |
TNFL9_HUMAN |
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| Protein Name |
Tumor necrosis factor ligand superfamily member 9 |
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| Primary Gene Name |
TNFSF9 |
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| Organism |
Homo sapiens (Human) |
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| Molecular Function |
Cytokine |
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| Membrane Location |
Membrane |
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| Substrate Name | CD137 ligand (4-1BBL) | |
| Cell Type | ||
| Substrate Description | cytokine that binds to TNFRSF9. Induces the proliferation of activated peripheral blood T-cells. | |
| Substrate Function Category | Immune and Inflammation | |
| Substrate Function Subtype | ||
| Sheddase | (unknown) | |
| Shedding-related Disease | cytokine | |
| Short Summary of Papers | soluble 4-1BBL was release released from the cell surface mediated by one or more sheddases and presented at high levels in the sera of some patients with various hematological diseases. the cleavage of 4-1BBL to an active soluble form would alter both proximal and distal cellular responses, including cell survival and costimulatory or inflammatory responses, that are mediated through the 4-1BB pathway | |
| Cleavage Information | NONE | |
| PMID | 11564827 |
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Start | End |
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29 | 49 |
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50 | 254 |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| PAPER | No_information | (unknown) | 11564827 | |||||