UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

P41047
Entry Name

TNFL6_MOUSE
Protein Name

Tumor necrosis factor ligand superfamily member 6
Primary Gene Name

Faslg
Organism

Mus musculus (Mouse)
Molecular Function

Cytokine
Repressor
Membrane Location

Secreted
Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name Fas ligand
Cell Type endothelial cell, monocytes, lymphocytes, neutrophils
Substrate Description Leukocyte Recruitment - Leukocyte and endothelial cell activation and immune modulation
Substrate Function Category Immune and Inflammation
Substrate Function Subtype Immune and Inflammation; cytokine
Sheddase MMP7
Shedding-related Disease cytokine
Short Summary of Papers inhibit cytotoxic activity
Cleavage Information NONE
PMID 16565325 11212252



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Transmembrane
 		79 100
Extracellular
 		101 279



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
MEROPS LQKE*LAEL 108 matrix metallopeptidase-7 physiologically relevant NONE 12464266   
PMAP LQKE*LAEL 108 matrix metallopeptidase-7 This_entry_is_based_on_an_experiment. Mutagenesis 12464266   
MEROPS ELAE*LREF 111 matrix metallopeptidase-7 physiologically relevant NONE 12464266   
PMAP ELAE*LREF 111 matrix metallopeptidase-7 This_entry_is_based_on_an_experiment. Mutagenesis 12464266   
MEROPS TNQS*LKVS 119 matrix metallopeptidase-7 physiologically relevant NONE 12464266   
PMAP TNQS*LKVS 119 matrix metallopeptidase-7 This_entry_is_based_on_an_experiment. Mutagenesis 12464266   
PAPER No-information ADAM10 NONE NONE 17290285   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
SPD 22728825
locate 17986452