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| UniProt ID |
P40967 |
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| Entry Name |
PMEL_HUMAN |
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| Protein Name |
Melanocyte protein PMEL |
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| Primary Gene Name |
PMEL |
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| Organism |
Homo sapiens (Human) |
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| Molecular Function | ||
| Membrane Location |
Secreted |
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| Substrate Name | Melanocyte protein PMEL (Pmel17) | |
| Cell Type | ||
| Substrate Description | biogenesis of melanosomes.maturation of melanosomes from stage I to II | |
| Substrate Function Category | melanogenesis, melanosome | |
| Substrate Function Subtype | ||
| Sheddase | ADAM10, ADAM17 | |
| Shedding-related Disease | ||
| Short Summary of Papers | Pmel17 is subject to RIP (regulated intramembrane proteolysis) after ectodomain shedding by ADAM10 and 17 , the release of the Pmel17 ectodomain, which is critical for melanin amyloidogenesis | |
| Cleavage Information | NONE | |
| PMID | 19047044 19884326 |
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Start | End |
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596 | 616 |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| PAPER | No_information | ADAM10,ADAM17 | 19047044 | |||||
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|---|---|---|---|
| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| SPD | 22728825 | ||