UniProt Summary
UniProt ID

P40197

Entry Name

GPV_HUMAN

Protein Name

Platelet glycoprotein V

Primary Gene Name

GP5

Organism

Homo sapiens (Human)

Molecular Function

Membrane Location

Membrane




Biological Literature Report of Shedding
Substrate Name GPV
Cell Type platelet
Substrate Description platelet hemostasis
Substrate Function Category blood and homoeostasis
Substrate Function Subtype platelet; platelet glycoprotein
Sheddase ADAM17
Shedding-related Disease platelet (cell surface protein)
Short Summary of Papers regulate hemostatic function of platelets
Cleavage Information NONE
PMID 18951988



Cleavage Site Diagram



Topological Domains
Topological Domains
Start End
Extracellular
17 523
Transmembrane
524 544



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
MEROPS LLRA*QPFP 16 signal peptidase complex (animal) physiologically relevant Mass spectroscopy 12665801   
MEROPS PGPR*GPPP 476 thrombin physiologically relevant NONE 8407908   
PMAP PGPR*GPPP 476 thrombin This entry is based on an experiment 8407908   
PAPER No_information ADAM17 16179345    15691827   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
PAPER platelet 20962327
Sys-BodyFluid Urine 16948836
Sys-BodyFluid Plasma/Serum 18793429
Sys-BodyFluid Plasma/Serum 18795103
Sys-BodyFluid Plasma/Serum 16104056