|
|
||
|---|---|---|
| UniProt ID |
P40189 |
|
| Entry Name |
IL6RB_HUMAN |
|
| Protein Name |
Interleukin-6 receptor subunit beta |
|
| Primary Gene Name |
IL6ST |
|
| Organism |
Homo sapiens (Human) |
|
| Molecular Function |
Receptor |
|
| Membrane Location |
Secreted |
|
|
|
|---|
| Substrate Name | IL6ST(gp130) | |
| Cell Type | ||
| Substrate Description | signal-transducing molecule in the receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3. binding of IL6 to IL6R induces IL6ST homodimerization and formation of a high-affinity receptor complex | |
| Substrate Function Category | Immune and Inflammation | |
| Substrate Function Subtype | ||
| Sheddase | (unknown) | |
| Shedding-related Disease | cytokine receptor | |
| Short Summary of Papers | the soluble forms of the gp130 (interleukin-6 signal-transducing receptor component) via proteolytic cleavage may possess a potential to inhibit signal in human serum | |
| Cleavage Information | NONE | |
| PMID | 8353278 |
|
|
|---|
|
|
||
|---|---|---|
|
|
Start | End |
|
|
23 | 619 |
|
|
620 | 641 |
|
|
||||||||
|---|---|---|---|---|---|---|---|---|
| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| PAPER | No_information | (unknown) | 8353278 | |||||
|
|
|||
|---|---|---|---|
| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| PAPER | platelet | 20962327 | |
| Sys-BodyFluid | Seminal Fluid | 16709260 | |
| Sys-BodyFluid | Saliva | 18361515 | |
| Sys-BodyFluid | Cerebrospinal fluid | 18052119 | |
| Sys-BodyFluid | Cerebrospinal fluid | 17022648 | |
| Sys-BodyFluid | Urine | 16948836 | |
| Sys-BodyFluid | Plasma/Serum | 18793429 | |
| Sys-BodyFluid | Plasma/Serum | 14718574 | |
| HCSD | cancer (lung cancer) | 19776420 | |
| HCSD | cancer(prostate cancer) | 22908226 | |
| HCSD | cancer(23 cancer cell lines) | 20124221 | |
| HCSD | cancer(Head and neck squamous cell carcinoma) | 23665456 | |
| HCSD | cancer(colorectal cancer | 24418523 | |
| HCSD | cancer(breast cancer) | 24505115 | |
| HCSD | cancer(Liver metastasis in colorectal cancer) | 23443137 | |
| HCSD | cancer(colorectal cancer) | 22506683 | |
| HCSD | cancer(non small cell lung cancer) | 19655816 | |
| locate | 17986452 | ||