UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

P36897
Entry Name

TGFR1_HUMAN
Protein Name

TGF-beta receptor type-1
Primary Gene Name

TGFBR1
Organism

Homo sapiens (Human)
Molecular Function

Kinase
Serine/threonine-protein kinase
Transferase
Receptor
Membrane Location

Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name type I TGF-beta receptor
Cell Type
Substrate Description TGF-beta signaling, regulate various physiological and pathological processes
Substrate Function Category growth factor & growth hormone
Substrate Function Subtype
Sheddase ADAM17
Shedding-related Disease growth factor receptor (TGF-beta R)
Short Summary of Papers shedding of the type I TGF-β receptor by ADAM17 downregulates TGF-β signaling
Cleavage Information NONE
PMID 19595713



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		34 126
Transmembrane
 		127 147



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
PAPER No_information ADAM17 19595713   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
Sys-BodyFluid Urine 16948836