UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

P35968
Entry Name

VGFR2_HUMAN
Protein Name

Vascular endothelial growth factor receptor 2
Primary Gene Name

KDR
Organism

Homo sapiens (Human)
Molecular Function

Tyrosine-protein kinase
Developmental protein
Transferase
Kinase
Receptor
Membrane Location

Secreted
Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name vascular endothelial growth factor receptor 2 (VEGFR2,FLK1)
Cell Type
Substrate Description tyrosine-protein kinase that acts as a cell-surface receptor,essential role in the regulation of angiogenesis
Substrate Function Category angiogenesis
Substrate Function Subtype
Sheddase ADAM10
Shedding-related Disease cell receptor
Short Summary of Papers shedding of the VEGFR2 could modulate VEGFR2 signaling, it is hypothesis that ADAM10 may play a crucial role in angiogenic and atherosclerotic processes
Cleavage Information NONE
PMID 20814017



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		20 764
Transmembrane
 		765 785



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
PAPER No_information ADAM12 23458101   
PAPER No_information ADAM10 20814017   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
Sys-BodyFluid Plasma/Serum 16878292
Sys-BodyFluid Plasma/Serum 17553692