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| UniProt ID |
P35822 |
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| Entry Name |
PTPRK_MOUSE |
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| Protein Name |
Receptor-type tyrosine-protein phosphatase kappa |
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| Primary Gene Name |
Ptprk |
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| Organism |
Mus musculus (Mouse) |
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| Molecular Function |
Hydrolase |
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| Membrane Location |
Membrane |
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| Substrate Name | Receptor-type tyrosine-protein phosphatase kappa (PTPRK) | |
| Cell Type | ||
| Substrate Description | protein tyrosine phosphatase (PTP) family. Regulation of processes involving cell contact and adhesion such as growth control, tumor invasion, and metastasis. | |
| Substrate Function Category | disease | |
| Substrate Function Subtype | ||
| Sheddase | PC5 protease | |
| Shedding-related Disease | cancer (tumor invasion) | |
| Short Summary of Papers | shedding of the PTPK ectodomain is assumed to be linked to a net loss of molecules that are involved in homophilic binding and increase in cell motility(cancer cells) | |
| Cleavage Information | NONE | |
| PMID | 16404719 |
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Start | End |
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26 | 752 |
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753 | 774 |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| MEROPS | RTKR*EAGA | 643 | presenilin 1 | physiologically relevant | NONE | NONE | ||
| MEROPS | RTKR*EAGA | 643 | furin | physiologically relevant | NONE | NONE | ||
| PMAP | RTKR*EAGA | 643 | furin | This_entry_is_based_on_an_experiment. | Mutagenesis | 8474452 16648485 | ||
| PMAP | RTKR*EAGA | 643 | presenilin 1 | This_entry_is_based_on_an_experiment. | Mutagenesis | 8474452 16648485 | ||
| PMAP | No_information | ADAM10 peptidase | This_entry_is_based_on_an_experiment. | Mutagenesis | 8474452 16648485 | |||