UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

P35590
Entry Name

TIE1_HUMAN
Protein Name

Tyrosine-protein kinase receptor Tie-1
Primary Gene Name

TIE1
Organism

Homo sapiens (Human)
Molecular Function

Kinase
Tyrosine-protein kinase
Transferase
Receptor
Membrane Location

Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name Tie1
Cell Type
Substrate Description regulation of angiogenesis
Substrate Function Category angiogenesis
Substrate Function Subtype angiogenesis; receptor (Tyrosine-protein kinase receptor)
Sheddase metalloprotease
Shedding-related Disease cell receptor
Short Summary of Papers shedding of Tie1 may be an important mechanism for controlling signaling by Tie2.
Cleavage Information NONE
PMID 17728252



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		22 759
Transmembrane
 		760 784



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
MEROPS HVGA*AVDL 21 signal peptidase complex (animal) physiologically relevant N-terminal sequencing 15340161   
PAPER No_information metalloprotease 17728252   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
Sys-BodyFluid Plasma/Serum 17553692