UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

P35439
Entry Name

NMDZ1_RAT
Protein Name

Glutamate receptor ionotropic, NMDA 1
Primary Gene Name

Grin1
Organism

Rattus norvegicus (Rat)
Molecular Function

Ion channel
Receptor
Ligand-gated ion channel
Membrane Location

Postsynaptic cell membrane
Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name NMDA receptor
Cell Type
Substrate Description glutamate-gated ion channels,synaptic plasticity, synaptogenesis,neuronal functions in glutamate neurotransmission
Substrate Function Category central nervous system (neuron)
Substrate Function Subtype
Sheddase MMP3
Shedding-related Disease cell receptor
Short Summary of Papers MMPs are involved in the activity dependent alteration of NMDA receptor structure at postsynaptic membrane specializations in the CNS.
Cleavage Information ZNo-Human:
PMID 18629001



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		19 559
Transmembrane
 		560 580
Transmembrane
 		631 647
Extracellular
 		648 812
Transmembrane
 		813 833



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
MEROPS IVAP*LTIN 516 matrix metallopeptidase-7 physiologically relevant NONE 18644839   
PAPER S MMP3 18629001   
PAPER L MMP3 18629001   
PAPER No_information MMP3 18629001   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
NO_DATA NO_DATA NO_DATA