UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

P35070
Entry Name

BTC_HUMAN
Protein Name

Probetacellulin [Cleaved into: Betacellulin
Primary Gene Name

BTC
Organism

Homo sapiens (Human)
Molecular Function

Mitogen
Growth factor
Membrane Location

Secreted
Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name betacellulin (BTC)
Cell Type
Substrate Description EGFR signaling, various signals in cell proliferation, survival and migration
Substrate Function Category growth factor & growth hormone
Substrate Function Subtype growth factor (EGFR)
Sheddase ADAM17, ADAM10
Shedding-related Disease growth factor (EGFR)
Short Summary of Papers produce soluble mature growth factor (as soluble agonist of EGFR)
Cleavage Information NONE
PMID 14993236 11823465 18951988



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		32 118
Transmembrane
 		119 139



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
HPRD CVVA*DGNS 31 10940639   
HPRD DLFY*LRGD 111 10940639   
MEROPS DLFY*LRGD 111 ADAM17 peptidase not physiologically relevant NONE 11823465   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
SPD 22728825