UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

P33671
Entry Name

SDC3_RAT
Protein Name

Syndecan-3
Primary Gene Name

Sdc3
Organism

Rattus norvegicus (Rat)
Molecular Function

Membrane Location

Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name Syndecan-3
Cell Type
Substrate Description cell surface proteoglycan that may bear heparan sulfate. organization of cell shape by affecting the actin cytoskeleton
Substrate Function Category cell surface structure
Substrate Function Subtype
Sheddase metalloproteinase
Shedding-related Disease proteoglycan
Short Summary of Papers metalloproteinase-dependent shedding of syndecan-3 may modulate the biological function of this proteoglycan. syndecan-3 is subject to RIP (regulated intramembrane proteolysis) by presenilin/gamma-secretase following ectodomain shedding
Cleavage Information NONE
PMID 12929127 14504279



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		45 387
Transmembrane
 		388 408



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
PAPER No_information metalloproteinase 12929127   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
NO_DATA NO_DATA NO_DATA