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| UniProt ID |
P33151 |
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| Entry Name |
CADH5_HUMAN |
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| Protein Name |
Cadherin-5 |
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| Primary Gene Name |
CDH5 |
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| Organism |
Homo sapiens (Human) |
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| Molecular Function | ||
| Membrane Location |
Cell membrane |
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| Substrate Name | VE-cadherin | |
| Cell Type | endothelial cell | |
| Substrate Description | Leukocyte Recruitment, Cell-cell adhesion molecules involved in endothelial diapedesis | |
| Substrate Function Category | Immune and Inflammation | |
| Substrate Function Subtype | Immune and Inflammation; cell adhesion molecule | |
| Sheddase | Cat G(Cathepsin), NE(neutrophil elastase), MMP, ADAM10 | |
| Shedding-related Disease | cell adhesion molecule | |
| Short Summary of Papers | destabilize EC junctions, Increased endothelial permeability | |
| Cleavage Information | NONE | |
| PMID | 16565325 18951988 |
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Start | End |
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48 | 599 |
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600 | 620 |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| MEROPS | RQKR*DWIW | 47 | kallikrein-related peptidase 4 | physiologically relevant | consensus sequence | 15389820 | ||
| MEROPS | PSSF*TIKV | 137 | elastase-2 | physiologically relevant | N-terminal sequencing | 12584200 | ||
| MEROPS | SFTI*KVHD | 139 | cathepsin G | physiologically relevant | N-terminal sequencing | 12584200 | ||
| MEROPS | FTIK*VHDV | 140 | elastase-2 | physiologically relevant | N-terminal sequencing | 12584200 | ||
| MEROPS | TVLV*TLQD | 246 | cathepsin G | physiologically relevant | N-terminal sequencing | 12584200 | ||
| MEROPS | VTLQ*DIND | 249 | elastase-2 | physiologically relevant | N-terminal sequencing | 12584200 | ||
| MEROPS | TLQD*INDN | 250 | elastase-2 | physiologically relevant | N-terminal sequencing | 12584200 | ||
| MEROPS | NVKF*KFIL | 514 | peptidyl-Lys metallopeptidase | not physiologically relevant | Mass spectroscopy | NONE | ||
| MEROPS | REHT*KVHF | 548 | peptidyl-Lys metallopeptidase | not physiologically relevant | Mass spectroscopy | NONE | ||
| PAPER | No_information | ADAM10 | Gel electrophoresis | 18420943 | ||||
| PMAP | No_information | matrix metallopeptidase | This entry is based on an experiment | 12878166 | ||||
| PMAP | No_information | gingipain K | This entry is based on an experiment | Gel electrophoresis | 16988242 | |||
| PMAP | No_information | gingipain R2 | This entry is based on an experiment | Gel electrophoresis | 16988242 | |||
| PMAP | No_information | gingipain R1 | This entry is based on an experiment | Gel electrophoresis | 16988242 | |||
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|---|---|---|---|
| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| Sys-BodyFluid | Amniotic fluid | 17495049 | |
| Sys-BodyFluid | Plasma/Serum | 18793429 | |
| Sys-BodyFluid | Plasma/Serum | 18795103 | |
| Sys-BodyFluid | Plasma/Serum | 16104056 | |
| Sys-BodyFluid | Plasma/Serum | 16739989 | |
| Sys-BodyFluid | Plasma/Serum | 14718574 | |
| HCSD | cancer(pancreatic cancer) | 21625447 | |