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| UniProt ID |
P32971 |
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| Entry Name |
TNFL8_HUMAN |
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| Protein Name |
Tumor necrosis factor ligand superfamily member 8 |
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| Primary Gene Name |
TNFSF8 |
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| Organism |
Homo sapiens (Human) |
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| Molecular Function |
Cytokine |
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| Membrane Location |
Membrane |
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| Substrate Name | CD30 Ligand (CD153) | |
| Cell Type | lymphocytes | |
| Substrate Description | leukocyte proliferation and apotosis regulation, immune modulation | |
| Substrate Function Category | Immune and Inflammation | |
| Substrate Function Subtype | Immune and Inflammation; cytokine | |
| Sheddase | ADAM8 | |
| Shedding-related Disease | cytokine | |
| Short Summary of Papers | release the soluble sCD30 form (functionally active to CD30+T cells) | |
| Cleavage Information | NONE | |
| PMID | 12777399 24447865 |
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Start | End |
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38 | 62 |
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63 | 234 |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| PAPER | No_information | ADAM8 | 12777399 | |||||
| PMAP | No_information | ADAM17 peptidase | This entry is based on an experiment | Others | 11120787 | |||
| PMAP | No_information | ADAM10 peptidase | This entry is based on an experiment | Mutagenesis | 11120787 | |||
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| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| Sys-BodyFluid | Plasma/Serum | 14718574 | |