|
|
||
|---|---|---|
| UniProt ID |
P32926 |
|
| Entry Name |
DSG3_HUMAN |
|
| Protein Name |
Desmoglein-3 |
|
| Primary Gene Name |
DSG3 |
|
| Organism |
Homo sapiens (Human) |
|
| Molecular Function | ||
| Membrane Location |
Cell membrane |
|
|
|
|---|
| Substrate Name | Desmoglein-3 | |
| Cell Type | ||
| Substrate Description | cell junctions, desmosome | |
| Substrate Function Category | cell surface structure | |
| Substrate Function Subtype | cell adhesion molecule | |
| Sheddase | metalloproteinase | |
| Shedding-related Disease | desmosome (cell junction) | |
| Short Summary of Papers | extracellular domain shedding by metalloproteinase during disruption of the desmosome structure and apoptosis | |
| Cleavage Information | NONE | |
| PMID | 11500511 24665393 |
|
|
|---|
|
|
||
|---|---|---|
|
|
Start | End |
|
|
50 | 615 |
|
|
616 | 640 |
|
|
||||||||
|---|---|---|---|---|---|---|---|---|
| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| MEROPS | LRIE*TKGQ | 28 | meprin alpha subunit | not physiologically relevant | Mass spectroscopy | 21693781 | ||
| MEROPS | KGQY*DEEE | 33 | meprin alpha subunit | not physiologically relevant | Mass spectroscopy | 21693781 | ||
| MEROPS | GQYD*EEEM | 34 | meprin alpha subunit | not physiologically relevant | Mass spectroscopy | 21693781 | ||
| MEROPS | GQYD*EEEM | 34 | meprin beta subunit | not physiologically relevant | Mass spectroscopy | 21693781 | ||
| HPRD | RQKR*EWVK | 49 | Furin | 12586364 | ||||
| MEROPS | RQKR*EWVK | 49 | kallikrein-related peptidase 4 | physiologically relevant | consensus sequence | 15389820 | ||
| MEROPS | RQKR*EWVK | 49 | furin | physiologically relevant | NONE | 12586364 | ||
| PMAP | RQKR*EWVK | 49 | furin | This entry is based on an experiment | 12586364 | |||
| PAPER | TPMF*LLSR | 209 | UNKNOWN | Mass spectrometry | 33796845 | |||
| HPRD | DYAD*GAIS | 781 | Caspase 3, apoptosis-related cysteine peptidase | 11500511 | ||||
| MEROPS | DYAD*GAIS | 781 | caspase-3 | physiologically relevant | NONE | 11500511 | ||
| PMAP | DYAD*GAIS | 781 | caspase-3 | This entry is based on an experiment | 11500511 | |||
| PAPER | No_information | metalloproteinase | 11500511 | |||||
| PMAP | No_information | matrix metallopeptidase-2 | This entry is based on an experiment | Gel electrophoresis | 17448220 | |||
| PMAP | No_information | matrix metallopeptidase-9 | This entry is based on an experiment | Gel electrophoresis | 17448220 | |||
|
|
|||
|---|---|---|---|
| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| SPD | 22728825 | ||
| Sys-BodyFluid | Saliva | 17614365 | |
| Sys-BodyFluid | Saliva | 18361515 | |
| Sys-BodyFluid | Saliva | 16740002 | |
| Sys-BodyFluid | Saliva | 16103422 | |
| Sys-BodyFluid | Saliva | 15473691 | |
| Sys-BodyFluid | Plasma/Serum | 16083276 | |
| HCSD | cancer(23 cancer cell lines) | 20124221 | |
| HCSD | cancer(Head and neck squamous cell carcinoma) | 23665456 | |
| HCSD | cancer(colon tumor) | 23684732 | |
| HCSD | cancer(head and neck squamous cell carcinoma) | 22918226 | |