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| UniProt ID |
P32004 |
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| Entry Name |
L1CAM_HUMAN |
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| Protein Name |
Neural cell adhesion molecule L1 |
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| Primary Gene Name |
L1CAM |
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| Organism |
Homo sapiens (Human) |
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| Molecular Function |
Developmental protein |
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| Membrane Location |
Cell membrane |
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| Substrate Name | L1 (neural cell adhesion molecule L1) | |
| Cell Type | CHO cells | |
| Substrate Description | cell migration; neurite outgrowth | |
| Substrate Function Category | central nervous system (neuron) | |
| Substrate Function Subtype | Central nervous system (CNS) pathology; cell adhesion molecules | |
| Sheddase | ADAM10 | |
| Shedding-related Disease | cell adhesion molecule | |
| Short Summary of Papers | shedding of L1 is necessary to promote migration. | |
| Cleavage Information | NONE | |
| PMID | 11706054 18951988 |
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Start | End |
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20 | 1120 |
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1121 | 1143 |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| MEROPS | PCLL*IQIP | 19 | signal peptidase complex (animal) | physiologically relevant | N-terminal sequencing | 3136168 | ||
| MEROPS | SQRK*HSKR | 860 | plasmin | physiologically relevant | NONE | 10574721 | ||
| PMAP | SQRK*HSKR | 860 | plasmin | This entry is based on an experiment | N-terminal sequencing | 10574721 | ||
| MEROPS | KHSK*RHIH | 863 | plasmin | physiologically relevant | NONE | 10574721 | ||
| PMAP | KHSK*RHIH | 863 | plasmin | This entry is based on an experiment | N-terminal sequencing | 10574721 | ||
| PAPER | No_information | ADAM10 | NONE | NONE | 11706054 | |||
| PMAP | No_information | ADAM10 peptidase | This entry is based on an experiment | 12475894 | ||||
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| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| PAPER | cancer(ovary) | 18560578 | |
| SPD | 22728825 | ||
| Sys-BodyFluid | Cerebrospinal fluid | 17853512 | |
| Sys-BodyFluid | Plasma/Serum | 16104056 | |
| HCSD | cancer (gastric cancer) | 23161554 | |
| HCSD | cancer (lung cancer) | 19776420 | |
| HCSD | cancer(prostate cancer) | 22908226 | |
| HCSD | cancer(Head and neck squamous cell carcinoma) | 23665456 | |
| HCSD | cancer(pancreatic cancer) | 16215274 | |
| HCSD | cancer(colorectal cancer | 22408128 | |
| HCSD | cancer(colorectal carsinoma) | 23585443 | |
| HCSD | cancer(colorectal cancer | 24418523 | |
| HCSD | cancer(pancreatic cancer) | 21625447 | |
| HCSD | cancer(ovarian cancer) | 23805888 | |
| HCSD | cancer(oral cancer ) | 21714544 | |
| HCSD | cancer(gastric cancer) | 22204653 | |