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|---|---|---|
| UniProt ID |
P31431 |
|
| Entry Name |
SDC4_HUMAN |
|
| Protein Name |
Syndecan-4 |
|
| Primary Gene Name |
SDC4 |
|
| Organism |
Homo sapiens (Human) |
|
| Molecular Function | ||
| Membrane Location |
Secreted |
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| Substrate Name | Syndecan-4 | |
| Cell Type | ||
| Substrate Description | cell migration, cell morphogenesis | |
| Substrate Function Category | disease | |
| Substrate Function Subtype | ||
| Sheddase | (unknown) | |
| Shedding-related Disease | atrial fibrillation (AF) | |
| Short Summary of Papers | Synd4 shedding is a molecular pathological alteration in the development and maintenance of inflammation-associated atrial fibrillation (AF) | |
| Cleavage Information | NONE | |
| PMID | 26261514 |
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|---|---|---|
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Start | End |
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19 | 145 |
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146 | 170 |
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|---|---|---|---|---|---|---|---|---|
| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| PAPER | ESIR*ETEV | 22 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | SIRE*TEVI | 23 | UNKNOWN | Mass spectrometry | 33796845 | |||
| MEROPS | DDLE*DSMI | 70 | meprin beta subunit | not physiologically relevant | Mass spectroscopy | 21693781 | ||
| MEROPS | DDLE*DSMI | 70 | meprin alpha subunit | not physiologically relevant | Mass spectroscopy | 21693781 | ||
| MEROPS | VIPK*RISP | 114 | thrombin | physiologically relevant | NONE | 16087677 | ||
| MEROPS | VIPK*RISP | 114 | plasmin | physiologically relevant | NONE | 16087677 | ||
| PMAP | VIPK*RISP | 114 | plasmin | This entry is based on an experiment | 16087677 | |||
| PMAP | VIPK*RISP | 114 | thrombin | This entry is based on an experiment | 16087677 | |||
| MEROPS | VSNK*VSMS | 128 | plasmin | physiologically relevant | NONE | 16087677 | ||
| PMAP | VSNK*VSMS | 128 | plasmin | This entry is based on an experiment | 16087677 | |||
| PAPER | S*M | 130 | MT1-MMP | 23384311 | ||||
| PAPER | KVSM*SSTV | 131 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | VSMS*STVQ | 132 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | SMSS*TVQG | 133 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | MSST*VQGS | 134 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | N*I | 139 | MT1-MMP | 23384311 | ||||
| PAPER | LIVG*GIVG | 153 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | No_information | (unknown) | 26261514 | |||||
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|---|---|---|---|
| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| PAPER | platelet | 20962327 | |
| PAPER | cancer(ovary) | 18560578 | |
| Sys-BodyFluid | Urine | 16948836 | |
| HCSD | cancer (gastric cancer) | 23161554 | |
| HCSD | cancer (lung cancer) | 19776420 | |
| HCSD | cancer(prostate cancer) | 22908226 | |
| HCSD | cancer(23 cancer cell lines) | 20124221 | |
| HCSD | cancer(Head and neck squamous cell carcinoma) | 23665456 | |
| HCSD | cancer(pancreatic cancer) | 16215274 | |
| HCSD | cancer(colon tumor) | 23684732 | |
| HCSD | cancer(colorectal cancer | 22408128 | |
| HCSD | cancer(colorectal carsinoma) | 23585443 | |
| HCSD | cancer(colorectal cancer | 24418523 | |
| HCSD | cancer(head and neck cancer) | 21598386 | |
| HCSD | cancer(pancreatic cancer) | 21625447 | |
| HCSD | cancer(ovarian cancer) | 23805888 | |
| HCSD | cancer(ovarian cancer) | 22623176 | |
| HCSD | cancer(oral cancer ) | 21714544 | |
| HCSD | cancer(gastric cancer) | 22204653 | |
| HCSD | cancer(Liver metastasis in colorectal cancer) | 23443137 | |
| HCSD | non-small cell lung cancer | 21262398 | |
| HCSD | cancer(non small cell lung cancer) | 19655816 | |
| HCSD | cancer(colorectal cancer) | 25216327 | |