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|---|---|---|
| UniProt ID |
P29965 |
|
| Entry Name |
CD40L_HUMAN |
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| Protein Name |
CD40 ligand |
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| Primary Gene Name |
CD40LG |
|
| Organism |
Homo sapiens (Human) |
|
| Molecular Function |
Cytokine |
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| Membrane Location |
Secreted |
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|---|
| Substrate Name | CD40L(CD154) | |
| Cell Type | endothelial cell, monocytes | |
| Substrate Description | cell activation and immune modulation, cell migration | |
| Substrate Function Category | Immune and Inflammation | |
| Substrate Function Subtype | Immune and Inflammation; cytokine | |
| Sheddase | ADAM17 | |
| Shedding-related Disease | cytokine | |
| Short Summary of Papers | inhibition of endothelial cell migration, activation of platelet aggregation, enhanced monocyte tissue factor expression and thrombin generation | |
| Cleavage Information | NONE | |
| PMID | 18951988 |
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Start | End |
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23 | 46 |
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47 | 261 |
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|---|---|---|---|---|---|---|---|---|
| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| MEROPS | SFEM*QKGD | 113 | ADAM10 peptidase | physiologically relevant | NONE | 12135759 | ||
| PMAP | No_information | ADAM17 peptidase | This entry is based on an experiment | Others | 12810728 | |||