UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

P29533
Entry Name

VCAM1_MOUSE
Protein Name

Vascular cell adhesion protein 1
Primary Gene Name

Vcam1
Organism

Mus musculus (Mouse)
Molecular Function

Membrane Location

Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name VCAM-1
Cell Type endothelial cell
Substrate Description Leukocyte Recruitment, Firm adhesion and locomotion to the endothelial cell junction
Substrate Function Category Immune and Inflammation
Substrate Function Subtype Immune and Inflammation; cell adhesion molecule
Sheddase NE(neutrophil elastase), ADAM17
Shedding-related Disease cell adhesion molecule
Short Summary of Papers de-adhesion,soluble adhesion antagonist
Cleavage Information NONE
PMID 16565325 15949468



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		25 698
Transmembrane
 		699 720



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
PAPER No_information ADAM17 NONE NONE 12878595   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
PAPER neuron 22728825