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| UniProt ID |
P29317 |
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| Entry Name |
EPHA2_HUMAN |
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| Protein Name |
Ephrin type-A receptor 2 |
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| Primary Gene Name |
EPHA2 |
|
| Organism |
Homo sapiens (Human) |
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| Molecular Function |
Tyrosine-protein kinase |
|
| Membrane Location |
Cell membrane |
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| Substrate Name | Ephrin-A2 | |
| Cell Type | Neuro-2a cells | |
| Substrate Description | neurite outgrowth | |
| Substrate Function Category | central nervous system (neuron) | |
| Substrate Function Subtype | Central nervous system (CNS) pathology; ligand | |
| Sheddase | ADAM10 | |
| Shedding-related Disease | ligand | |
| Short Summary of Papers | ephrin-A2 cleavage may provide a means for axon detachment and termination of signaling. | |
| Cleavage Information | NONE | |
| PMID | 10958785 |
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Start | End |
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24 | 537 |
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538 | 558 |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| PAPER | SDFE*ARHV | 157 | UNKNOWN | Mass spectrometry | 33796845 | |||
| ASCENT | ATVA*GTCV | 227 | UNKNOWN | subtiligase-based N-terminal sequencing | 33536314 | |||
| ASCENT | FRTA*SVSI | 430 | UNKNOWN | subtiligase-based N-terminal sequencing | 33536314 | |||
| ASCENT | TASV*SINQ | 432 | UNKNOWN | subtiligase-based N-terminal sequencing | 33536314 | |||
| ASCENT | VQVQ*ALTQ | 508 | UNKNOWN | subtiligase-based N-terminal sequencing | 33536314 | |||
| PAPER | QVQA*LTQE | 509 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | No_information | MT1-MMP | 23629968 | |||||
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|---|---|---|---|
| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| SPD | 22728825 | ||
| Sys-BodyFluid | Plasma/Serum | 17553692 | |
| HCSD | cancer (gastric cancer) | 23161554 | |
| HCSD | cancer (lung cancer) | 19776420 | |
| HCSD | cancer(prostate cancer) | 22908226 | |
| HCSD | cancer(23 cancer cell lines) | 20124221 | |
| HCSD | cancer(Head and neck squamous cell carcinoma) | 23665456 | |
| HCSD | cancer(colon tumor) | 23684732 | |
| HCSD | cancer(colorectal cancer | 24418523 | |
| HCSD | cancer(colorectal carsinoma) | 23585443 | |
| HCSD | cancer(head and neck squamous cell carcinoma) | 22918226 | |
| HCSD | cancer(breast cancer) | 24505115 | |
| HCSD | cancer(pancreatic cancer) | 21625447 | |
| HCSD | cancer(ovarian cancer) | 23805888 | |
| HCSD | cancer(oral cancer ) | 21714544 | |
| HCSD | cancer(Liver metastasis in colorectal cancer) | 23443137 | |
| HCSD | cancer(non small cell lung cancer) | 19655816 | |