UniProt Summary
UniProt ID

P28908

Entry Name

TNR8_HUMAN

Protein Name

Tumor necrosis factor receptor superfamily member 8

Primary Gene Name

TNFRSF8

Organism

Homo sapiens (Human)

Molecular Function

Receptor

Membrane Location

Cell membrane
Membrane




Biological Literature Report of Shedding
Substrate Name CD30
Cell Type lymphocytes
Substrate Description Leukocyte Recruitment, Leukocyte and endothelial cell activation and immune modulation
Substrate Function Category Immune and Inflammation
Substrate Function Subtype Immune and Inflammation; cytokine receptor
Sheddase ADAM17
Shedding-related Disease cytokine receptor
Short Summary of Papers soluble receptor generated by shedding may be functioned in immunosuppression
Cleavage Information NONE
PMID 16565325 11120787



Cleavage Site Diagram



Topological Domains
Topological Domains
Start End
Extracellular
19 385
Transmembrane
386 406



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
PAPER No_information ADAM17 11120787   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
Sys-BodyFluid Amniotic fluid 17495049
Sys-BodyFluid Plasma/Serum 16104056
Sys-BodyFluid Plasma/Serum 14718574
locate 17986452