UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

P28843
Entry Name

DPP4_MOUSE
Protein Name

Dipeptidyl peptidase 4
Primary Gene Name

Dpp4
Organism

Mus musculus (Mouse)
Molecular Function

Hydrolase
Serine protease
Aminopeptidase
Receptor
Protease
Membrane Location

Secreted
Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name Dipeptidyl peptidase 4 (CD26,DPP4)
Cell Type
Substrate Description cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation.
Substrate Function Category Immune and Inflammation
Substrate Function Subtype
Sheddase MMP1, MMP2, MMP9, MMP14
Shedding-related Disease cell receptor
Short Summary of Papers shedding of immune complexes (containing DPP IV) into vascular and extravascular fluids results in loss of DPP IV from the cell surface. may have relevance to hyperacute rejection; shedding of dipeptidyl peptidase 4 is mediated by metalloproteases and up-regulated by hypoxia in human adipocytes and smooth muscle cells.
Cleavage Information NONE
PMID 8878393 25217834



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Transmembrane
 		7 28
Extracellular
 		29 760



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
PAPER No_information (unknown) 8878393   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
SPD 22728825