UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

P28827
Entry Name

PTPRM_HUMAN
Protein Name

Receptor-type tyrosine-protein phosphatase mu
Primary Gene Name

PTPRM
Organism

Homo sapiens (Human)
Molecular Function

Hydrolase
Protein phosphatase
Receptor
Membrane Location

Membrane



Biological Literature Report of Shedding
Substrate Name Receptor-type tyrosine-protein phosphatase mu (RPTPĪ¼)
Cell Type
Substrate Description cell adhesion through homophilic interactions. May play a key role in signal transduction and growth control.
Substrate Function Category enzyme
Substrate Function Subtype
Sheddase PC5 protease
Shedding-related Disease receptor-type PTPases
Short Summary of Papers released RPTP fragments may retain the capacity for homotypic binding and antagonize interactions between RPTP on the surface of adjacent cell; proteolytic cleavage of RPTPĪ¼ regulates Glioblastoma cell migration
Cleavage Information NONE
PMID 8620001 19690139



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		21 742
Transmembrane
 		743 764



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
MEROPS RPRR*TKKT 632 PCSK5 peptidase physiologically relevant NONE NONE   
PAPER No_information PC5 protease 8620001   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
SPD 22728825
Sys-BodyFluid Cerebrospinal fluid 18052119
Sys-BodyFluid Urine 16948836
Sys-BodyFluid Plasma/Serum 16878292
Sys-BodyFluid Plasma/Serum 12917320
Sys-BodyFluid Plasma/Serum 16104056
Sys-BodyFluid Plasma/Serum 14718574
HCSD cancer(prostate cancer) 22908226
HCSD cancer(Head and neck squamous cell carcinoma) 23665456
HCSD cancer(ovarian cancer) 23805888
HCSD non-small cell lung cancer 21262398