UniProt Summary
UniProt ID

P28825

Entry Name

MEP1A_MOUSE

Protein Name

Meprin A subunit alpha

Primary Gene Name

Mep1a

Organism

Mus musculus (Mouse)

Molecular Function

Hydrolase
Protease
Metalloprotease

Membrane Location

Membrane




Biological Literature Report of Shedding
Substrate Name meprin α
Cell Type
Substrate Description metalloendopeptidases, hydrolysis of protein and peptide substrates
Substrate Function Category enzyme
Substrate Function Subtype
Sheddase furin
Shedding-related Disease protease (metalloproteinase)
Short Summary of Papers proteolytic cleavage during biosynthesis to generate mature form
Cleavage Information NONE
PMID 25617491 9439598



Cleavage Site Diagram



Topological Domains
Topological Domains
Start End
Extracellular
65 713
Transmembrane
714 741



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
MEROPS HIAA*VSIK 20 signal peptidase complex (animal) physiologically relevant N-terminal sequencing 8615815   
MEROPS PRTR*NAMR 64 cationic trypsin (Homo sapiens-type) physiologically relevant NONE 9346968   
PAPER No_information furin 9439598   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
NO_DATA NO_DATA NO_DATA